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Therefore, the pharmacokinetics information must be taken into account for rational design of CPP-based drug delivery, of which Mier and his colleagues provide a summary about the targeting and biodistribution issues. In particular, they summarized the strategy of using targeting motifs to modify the CPPs for altering their bio-fate. He et al. The activation is specifically triggered by the tumor-associated factors e. UV or exogenous agents. Of note, blood-brain barrier represents one of the most difficult challenges against effective drug delivery to the central nervous system, and Chen and his colleagues describe the promising CPP-based brain delivery techniques, in which CPPs play an important role in overcoming the formidable barrier.
Topical application of CPP may benefit from its local action, because of limiting the unwanted wide drug distribution. Huang and Moon et al. Wang and He et al. Due to charge interaction, conjugation of insulin with CPP still remains a problem, and they proposed a proper selection of linker would be helpful. Sun et al. They mainly discuss the noninvasive vaccination based on CPP-mediated delivery including protein, peptide and DNA vaccines.
Last but not least, Lee and his colleagues focus on an interesting topic of CPP-mediated delivery by non-covalent forms, which is featured by its ease to produce and use, and versatility to various types of cargos without the need of custom-tailored conjugation processes, compared to the chemical method. Prospects for clinical translation of CPP-based therapy have emerged, and some clinical trials have been well underway .
Abstract: In recent years biomacromolecular drugs including proteins and nucleic acids have been emerging among the most promising therapeutics and globally recognized as one of the most cutting-edge areas of drug research. There are many chemotherapeutic interventions available for tuberculosis TB and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant strains. Moreover, the ability of Mycobacterium tuberculosis Mtb to survive within granulomas in a non-replicating latent stage prolongs the course of drug dose and hence increases the severity of the disease.
The significant rerouting of metabolism is one of the key processes that help mycobacteria adapt to the hostile environment of host granuloma. In this review, we are focusing on some of the cofactor biosynthetic pathways of Mycobacterium tuberculosis and their utilization as drug targets. Abstract: There are many chemotherapeutic interventions available for tuberculosis TB and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant strains.
Box , Belgrade, Serbia. It is now recognized that inflammatory processes regulate all stages of atherosclerosis, from disease initiation to thrombotic complications. C-reactive protein CRP is a plasmatic protein used as a general marker of inflammation. The high sensitivity C-reactive protein hsCRP refers to the measurement of CRP in blood samples using assays with sufficient sensitivity to quantify low baseline levels of this biomarker. Low-grade chronic inflammatory processes are linked to atherosclerosis and may be screened with the use of hsCRP, thus providing additional information in cardiovascular risk prediction.
This review elaborates the role of CRP in atherogenesis and the value of hsCRP as a biomarker in cardiovascular risk prediction in both primary and secondary prevention setting. Keywords: Atherogenesis, biomarker, cardiovascular disease, C-reactive protein, high sensitivity C-reactive protein, inflammation, prevention. Abstract: It is now recognized that inflammatory processes regulate all stages of atherosclerosis, from disease initiation to thrombotic complications.
The grafting efficiency and the amount of grafted polymer were evaluated by thermal gravimetric analysis TGA. The colloidal stability testing suggested that the surface-grafted HAP retained higher dispersibility in methylene chloride than pure HAP nanoparticles did. Moreover, the dispersity of the modified particles was significantly improved with the increasing amount of PCL grafted.
In particular, it was found that the compressive modulus of the surface-grafted HAP with Content Access Key:. Journal Name: Current Radiopharmaceuticals. Volume 7 , Issue 1 , Journal Home. This appears to be driven by improved discovery of small. Close Print this page. Content: Citation Only. Citation and Abstract. Cite this article as: Sean L.
Article Metrics PDF: Volume 9 , Issue 1 , Current: 2. Journal Name: Current Pharmaceutical Biotechnology. She and Dr. Watson have collaborated extensively on both laboratory research and editing. We are always looking for ways to improve customer experience on Elsevier. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.
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The Journal of Physical Chemistry A , 30 , Scott P. Nichols, Ahyeon Koh, Wesley L. Chemical Reviews , 4 , Larry K. Fifty Years of Diazeniumdiolate Research. ACS Chemical Biology , 6 11 , Chemistry of Materials , 23 18 , Debra J. Salmon, Claudia L. Peterson, Gens P.
Goodman, Joseph E. Saavedra, Aloka Srinivasan, Keith M. Davies, Larry K. Keefer, and Katrina M. Inorganic Chemistry , 50 8 , Langmuir , 26 15 , Jens Hartung. Chemical Reviews , 9 , Hua Xu, Melissa M. Reynolds, Keith E. Cook, Anthony S. Evans and John P. Organic Letters , 10 20 , Evan M. Stasko, C. Bryce Johnson, Daniel A. Wespe, Ekhson Holmuhamedov, Mark H. ACS Nano , 2 2 , Jae Ho Shin and Mark H.
Chemistry of Materials , 20 1 , Harinath Chakrapani,, Brett M.
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Showalter,, Michael L. Citro,, Larry K. Keefer, and, Joseph E. Organic Letters , 9 22 , Sergei V. Lymar and, Vladimir Shafirovich. The Journal of Physical Chemistry B , 24 , Mark A. Polizzi,, Nathan A. Stasko, and, Mark H. Langmuir , 23 9 , Zhengrong Zhou,, Gail M. Annich,, Yiduo Wu, and, Mark E. Biomacromolecules , 7 9 , Nathan A. Stasko and, Mark H. Dendrimers as a Scaffold for Nitric Oxide Release. Journal of the American Chemical Society , 25 , Melissa M.
Reynolds,, Joseph A. Hrabie,, Bong K. Oh,, Jeffrey K. Politis,, Michael L. Keefer, and, Mark E. Biomacromolecules , 7 3 , Andrew S. Dutton,, Christopher P. Suhrada,, Katrina M. Miranda,, David A.
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Wink,, Jon M. Fukuto, and, K. Inorganic Chemistry , 45 6 , Crisjoe A. Joseph,, Matthew S. Lee,, Alexei V. Iretskii,, Guang Wu, and, Peter C.
Inorganic Chemistry , 45 5 , Journal of the American Chemical Society , 33 , Aaron R. Rothrock,, Robert L. Donkers, and, Mark H. Journal of the American Chemical Society , 26 , Reynolds,, Zhengrong Zhou,, Bong K. Oh, and, Mark E. Organic Letters , 7 14 , Joseph and, Peter C. Journal of the American Chemical Society , 18 , Zhengrong Zhou and, Mark E. Biomacromolecules , 6 2 , Brian J. Nablo and, Mark H. Biomacromolecules , 5 5 , Jae Ho Shin,, Stephanie M.
Marxer, and, Mark H. Analytical Chemistry , 76 15 , Dutton,, Jon M. Inorganic Chemistry , 43 3 , Batchelor,, Sylvie L. Reoma,, Paul S. Fleser,, Vijay K. Nuthakki,, Rose E. Callahan,, Charles J. Shanley,, Jeffrey K. Politis,, Jessica Elmore,, Scott I. Merz, and, Mark E. Journal of Medicinal Chemistry , 46 24 , Huiping Zhang,, Gail M. Merz,, Robert H. Bartlett, and, Mark E.
Journal of the American Chemical Society , 17 , Stacy E. Saavedra,, Joseph A. Hrabie, and, Keith M. Langmuir , 19 6 , Keefer , Joseph E. Journal of Chemical Education , 79 12 , Pawel G. Parzuchowski,, Megan C. Frost, and, Mark E. Journal of the American Chemical Society , 41 , Adrian C.
Nicolescu,, Sergei I. Zavorin,, Nicholas J. Turro,, James N. Reynolds, and, Gregory R. Chemical Research in Toxicology , 15 7 , Peter C. Ford and, Ivan M. Joseph A. Hrabie and, Larry K. Mark D. Lim,, Ivan M. Lorkovic, and, Peter C. Kinetics of the Oxidation of Triphenylphosphine by Nitric Oxide. Inorganic Chemistry , 41 4 , Journal of the American Chemical Society , 42 , Saavedra,, Alexander V.
Nikolaitchik,, Daniel A. Brady,, Emily Yourd,, Keith M.
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Davies,, Larry K. Keefer, and, John P. Chemistry of the Diazeniumdiolates. Journal of the American Chemical Society , 23 , Sean Hopkins, Megan Frost. Bioengineering , 5 3 , John M. Goodwin, Carol A. Chrestensen, Ellen W. Polymers , 9 11 , ChemBioChem , 18 15 , Pokidova, N. Sanina, L. Syrtsova, B. Psikha, N. Shkondina, A. Kotelnikov, S. Russian Chemical Bulletin , 66 3 , A photodynamic bifunctional conjugate for prostate cancer: an in vitro mechanistic study. Investigational New Drugs , 35 1 , Basudhar, G. Bharadwaj, D.
Salmon, K. HNO Donors. Samuel K. Nitric Oxide Donors as Antimicrobial Agents.
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Weilue He, Megan C. Direct measurement of actual levels of nitric oxide NO in cell culture conditions using soluble NO donors. Redox Biology , 9 , Kovalchukova, Nasrin Namichemazi, A. Bostanabad, A. Stash, S. Strashnova, I. Complexes of some tervalent metals with N-alkyl benzyl nitrozohydroxylamine derivatives.